PKM and breast cancer: PKM2 is highly expressed in tumour cells in the form of low enzyme activity dimer, which helps to combine carbon atoms into bioactive substances more quickly, promote the rapid generation of energy from glycolysis intermediates and flow into collateral pathways and synthesize nucleic acids, amino acids and lipids without accumulating reactive oxygen species to provide energy and metabolic substances needed for the malignant growth of breast cancer cells.28, 29