Hypoxia can induce the expression of hypoxia inducible factor‐1α (HIF1α) through transcription to inhibit the expression of miR‐16‐5p, and promote the expression of YTH domain family 1 (YTHDF1), and thus enhance the expression of PKM2 through m6A methylation to enhance tumour glycolysis and ultimately increase the tumorigenesis and metastasis ability of breast cancer cells.31 This evidence concerns the gene PKM and breast carcinoma.