PKM and neoplasm: Hypoxia can induce the expression of hypoxia inducible factor‐1α (HIF1α) through transcription to inhibit the expression of miR‐16‐5p, and promote the expression of YTH domain family 1 (YTHDF1), and thus enhance the expression of PKM2 through m6A methylation to enhance tumour glycolysis and ultimately increase the tumorigenesis and metastasis ability of breast cancer cells.31