Compared to 786-O and A498, sunitinib-resistant ccRCC cell lines 786-Su and A498-Su presented an aberrant overexpression of Axl and PD-L1, as well as a decreased phosphorylation of members of the STAT3 pathway and of LDHA (Figure 1(c)). Here, STAT3 is linked to nonpapillary renal cell carcinoma.