Treatment of Ifne-/- mice is also unable to restore CD69+ populations of active NK cells (CD69+IFNγ+, p = 0.338; CD69+IFNγ-, p = 0.221) during infection, however, there are increases in inactive CD69-IFNγ- NK cells to similar levels as in WT mice (Figs. 7B–F and EV5A,B). The gene discussed is IFNG; the disease is infection.