Transferring GFP-shMCT1- or GFP-shLDHB-expressing OT-1 T cells (Fig. 4h and Extended Data Fig. 7k), we found that LC-mediated tumor growth inhibition was abrogated by MCT1 or LDHB knockdown (Extended Data Fig. 7l), and LC treatment only increased the infiltration of shNC OT-1 T cells, but not shMCT1 or shLDHB T cells, into OVA-B16 tumors and upregulated IFN-γ and CD107a expression (Fig. 4i). The gene discussed is IFNG; the disease is neoplasm.