There was almost no evidence that suggested the association of genetically predicted CRP level with all BC (Table 1) (OR 1.05, 95% CI 0.98–1.12, P = 0.2059), ER + BC risk (OR 1.07, 95% CI 0.98–1.17, P = 0.1340), and ER-BC (OR 1.04, 95% CI 0.94–1.15, P = 0.4396). The gene discussed is CRP; the disease is breast cancer.