CD4+T cell can be divided into Th1, Th2, regulatory T cells (Treg), etc. It is currently believed that Th1 cells mediate anti-tumor immunity, while Th2 and Treg cells have pro-tumorigenic effects due to their immunosuppressive properties (Ruffell et al. 2010; Zamarron and Chen 2011). Here, CD4 is linked to neoplasm.