Indicators with statistically significant results in the univariate analysis were included as independent variables in a multifactorial logistic regression model, which showed that CD3+T, CD4+T, CD4+/CD8+, DNT, and LMR were independent risk factors for the development of malignant tumors in the breast (P = 0.001, < 0.001, = 0.043, = 0.025, < 0.001) (Table 2). The gene discussed is CD4; the disease is cancer.