Moreover, we analyzed the effects of these two demethylases on the prognosis of NPC patients in detail through Kaplan‒Meier survival curves: we found that the prognosis of NPC patients with high expression of both FTO and ALKBH5 was much worse than that of patients with low expression of both FTO and ALKBH5 (Fig. 1J). The gene discussed is MBD2; the disease is nasopharyngeal carcinoma.