Subsequently, in the xenotransplantation model of nude mice, it was found that knockdown of FTO or ALKBH5 expression could inhibit the growth and metastasis of NPC, while knockdown of a single demethylase alone had a short-acting effect on NPC, and their inhibitory effects decreased and even disappeared with time. The gene discussed is MBD2; the disease is nasopharyngeal carcinoma.