Our results linking BCDIN3D, EPRS and LRPPRC are particularly intriguing given the association of BCDIN3D locus with obesity and type II diabetes in humans (Berndt et al, 2013; Reinsborough et al, 2021; Thorleifsson et al, 2009; Walley et al, 2009), and the results from the Fox lab (Arif et al, 2017) showing that EPRS linker S999 phospho-deficient mutants have reduced adipose tissue mass, and increased lifespan. Here, LRPPRC is linked to type 2 diabetes mellitus.