We next asked if silencing LONP1 could reduce inflammation during infection and found that IL-6 production was dampened upon S. Typhimurium infection by silencing LONP1 (Fig. 7H) or pharmacologically inhibiting LONP1 (Appendix Fig. S7F), or upon inhibition of complex I using Rotenone (Appendix Fig. S7G). The gene discussed is IL6; the disease is infection.