TFEB and infection: TFEB regulates inflammation and immunity upon infection in macrophages in a transcriptional program conserved in the nematode Caenorhabditis elegans (Pastore et al, 2016; Visvikis et al, 2014) with recent data indicating mitochondrial metabolism may contribute to the effector function of TFEB activated macrophages (Schuster et al, 2022).