Only limited numbers of studies have demonstrated the prognostic importance of the immune microenvironment and druggable markers in sarcoma with heterogenous significance23–26; Sorbye et al. reported a significant association of CD20 + B peritumoral lymphocytes with disease free survival25 and PD-L1 or NK cells were also reported as significant prognostic factors with multiple STS23,25. The gene discussed is CD274; the disease is sarcoma.