AKT1 and Familial prostate cancer: To further explore the role of ME2fl phosphorylation by AKT1 in tumorigenesis in vivo, we used age-matched and genetic background-matched Pb-Cre-PtenL/L mice as controls to monitor tumor development in the Pb-Cre+PtenL/L prostate cancer model26,27 (Supplementary Fig. 13c).