Two of the 49 traits were PD and proxy-PD (first-degree relative), which is consistent with the identification of the genes (LINC02210, KANSL1, TMEM175, CD38, MMRN1, RAB29, STX4, PRSS36, GPNMB, NUPL2, KAT8, KLHL7-AS1, and ARHGAP27) being causally linked to PD, as the loci containing the regulatory sceQTLs have previously been associated with PD risk through GWAS. The gene discussed is GPNMB; the disease is Parkinson disease.