Survival maps from the GEPIA2 database showed that among the 33 analyzed cancer types, increased expressions of ADAMTS1, L1CAM, and EGFR were only significantly associated with poor survival in HNSCC (Fig. 4I), implying the critical and specific role of the ADAMTS1-L1CAM-EGFR axis in HNSCC progression. This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.