In the clinic, we observed significantly higher L1CAM levels in tumors compared to adjacent normal tissues, regardless of whether in HNSCC (Fig. 3E) or OSCC (Supplementary Fig. 4) cohorts from TCGA database, and high L1CAM in tumors was correlated with shorter OS and DSS times in HNSCC patients (Fig. 3F). The gene discussed is L1CAM; the disease is head and neck squamous cell carcinoma.