L1CAM and pancreatic neoplasm: In addition, L1CAM-integrin binding was shown to induce interleukin (IL)-1β production in pancreatic cancers [50], and IL-1β was reported to transactivate EGFR in OSCC [51], implying that the interaction of L1CAM and integrin might promote EGFR activation via inducing IL-1β upregulation in OSCC.