ADAMTS1 and cancer: At the end of the experiment, most mice had spontaneously developed cervical LN metastasis within 35 days after cancer cell injection, and frequencies of LN metastasis were higher and lower in mice respectively injected with HSC-3/ADAMTS1 and HSC-3M/shADAMTS1 cells compared to their respective control groups (Fig. 2E, F, upper panel).