No difference was observed in serum TNF and IL-10 protein concentration between WT and Del1−/− neonate pups (Supplementary Fig. 3a, b) or between Del1−/− neonate pups treated either with i.v. DEL-1-Fc or control IgG, 6 hours following CS-induced sepsis (Supplementary Fig. 3c, d). The gene discussed is TNF; the disease is Sepsis.