To delineate the mechanism of DEL-1-mediated protection against neonatal sepsis, we evaluated cytokine responses, neutrophil infiltration, phagocytosis capacity, and bacteria clearance in WT and Del1−/− neonate mice in the presence or absence of exogenous DEL-1 administration using DEL-1-Fc21,24. The gene discussed is EDIL3; the disease is Sepsis.