DEL-1 expression is transiently suppressed locally in tissues in response to pro-inflammatory triggers in adult mouse models of LPS-induced lung injury, cecal ligation and puncture (CLP)-induced sepsis, inflammatory bone loss, experimental autoimmune encephalomyelitis and sepsis-induced adrenal gland inflammation8,14,20,21,25,39. Here, EDIL3 is linked to experimental autoimmune encephalomyelitis.