Although DEL-1 deficiency had no significant effect on long-term HSC (LT-HSCs) and short-term HSC (ST-HSCs) population (Lin–cKit+Sca1+CD48– CD150–), we observed a significant decrease in the number of multipotent progenitors (MPPs, Lin−Sca-1+cKit+CD48+CD150−) and particularly the myeloid-biased MPP3 lineage (MPP3s, Lin−Sca-1+cKit+Flt3−CD48+CD150−) in Del1−/− mice, upon polymicrobial sepsis (Fig. 7a–d)33,35. The gene discussed is EDIL3; the disease is Sepsis.