IL10 and Sepsis: Consistent with these findings in mouse tissues, the median human serum DEL-1 protein concentration was higher in septic adults and septic neonates that exhibited high (>2) serum IL-10 to IL-17A ratio, compared to those with low (<2) IL-10 to IL-17A ratio (Fig. 9h), further supporting that the IL-10/IL-17A balance regulates DEL-1 levels in sepsis.