Su et al. reported that miR-155 in EC-EVs could ameliorate osteoporosis in vitro and in vivo.132 Interestingly, the authors compared the effects of exogenous EV injection on the distribution of ECs, BMSCs, and bone cells, and found that only ECs-EVs were enriched in bone tissue.132 The author speculated that the protein (PZP) expressed in these ECs-EVs may be the leading cause of this phenomenon.132 Generally, the evidence suggests that EC-EVs promote osteoma to inhibit osteoporosis. This evidence concerns the gene PZP and osteoporosis.