For example, Hua et al. analyzed circRNAs in the serum EVs of osteoporosis patients using a circRNA microarray and qRT‒PCR.176 Their results confirmed that Hsa_circ_0006859 expression was significantly upregulated in the exosomes of osteoporosis patients compared with healthy controls, suggesting that Hsa_circ_0006859 could serve as a biomarker for postmenopausal osteoporosis.176 In addition, in vitro experiments confirmed that hsa_circ_0006859 inhibited osteogenesis and promoted adipogenesis by upregulating ROCK1 by sponging miR-431-5p.176. The gene discussed is ROCK1; the disease is osteoporosis.