ANXA5 and cancer: Next, flow cytometric analysis of Annexin V+ cells revealed the following: (1) VP-16 treatment alone promoted cancer cell apoptosis to a certain extent, and (2) a significantly greater apoptotic rate was triggered in the combination group compared to the VP-16 monotherapy group, as shown by the observation that there is a remarkably higher proportion of Annexin V+ population in the combination group (Fig. 7G, H).