CASP3 and cancer: Likewise, the combination of VP-16 and RG7112 significantly increased caspase-3 and PARP cleavage (Fig. 7I, J), two characteristics of apoptosis [35], relative to those of VP-16 or RG7112 treatment alone, suggesting that RG7112 administration sensitizes cancer cells to VP-16 treatment by inducing apoptosis.