VHL and nonpapillary renal cell carcinoma: To explore the role of HIF2α in renal cancer cells, we stably inhibited HIF2α in three VHL(−/−) ccRCC cell lines (786-O, A498 and OS-RC-2) with lentiviruses carrying shRNA for HIF2α and a control nonspecific shRNA (LacZ) (Fig. 1D).