In addition, we also found that LINC02609, a HIF-2α-regulated long noncoding RNA could directly bind to miR-149-5p and effectively function as a sponge for miR-149-5p to modulate the expression of APOL1 in ccRCC (Fig. 7H). This evidence concerns the gene LINC02609 and nonpapillary renal cell carcinoma.