To dissect the mechanism of lipid deposition in renal cancer cells, we first evaluated the ability of a panel of three VHL (−/−) cancerous (786-O, A498 and OS-RC-2), three VHL (+/+) cancerous (ACHN, Caki-1 and SN12PM6) and one non-tumorigenic (HK-2) cell lines to make lipid droplets (Fig. 1A) [27]. This evidence concerns the gene VHL and renal carcinoma.