Additionally, variations in genes involved in α-syn metabolism and clearance, such as leucine-rich repeat kinase 2 gene (LRRK2), glucocerebrosidase gene (GBA), and parkin RBR E3 ubiquitin-protein ligase gene (PRKN), have also been implicated in PD pathogenesis [33]. The gene discussed is LRRK2; the disease is Parkinson disease.