In CTCL specifically, immunohistochemistry (IHC) has demonstrated persistent activation of components of this pathway, such as p-Akt, p-70S6K, and p-eukaryotic initiation factor 4E-binding protein (4E-BP1)74–76. The gene discussed is EIF4EBP1; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.