It has previously been shown that suppression of Pi3K/Akt/mTOR signaling in CTCL decreases chemotaxis of malignant cells by disrupting the C-X-C chemokine receptor (CXCR)4/C-X-C motif chemokine ligand (CXCL)12 axis52. This evidence concerns the gene CXCL12 and primary cutaneous T-cell non-Hodgkin lymphoma.