Although GZ17-6.02’s effects on this CXCR4/CXCL12 signaling have not previously been evaluated, curcumin has been shown to suppress these pathways in various malignancies including endometrial and colon cancers85,86 Prior studies have shown that therapeutic agents targeting the Pi3K/Akt/mTOR pathway reduce CXCL12 mediated migration of CTCL and chronic lymphocytic leukemia cells52,77. Here, CXCR4 is linked to B-cell chronic lymphocytic leukemia.