However, a desmocollin switch from DSC2 to DSC1/3 has been reported in CRC [5], in a similar way to the classical cadherin switching, or replacement of E-cadherin by N-cadherin, that has been associated with epithelial-mesenchymal transition (EMT) in multiple cancers [6]. The gene discussed is DSC2; the disease is colorectal carcinoma.