Considering the different effects reported for cadherins and catenins in cancer progression according to the cell phenotype, we explored the interactome of CDH17 in two different CRC cell lines, RKO and HT-29, representatives of undifferentiated CMS4 and colon-like CMS3 subtypes, respectively [26] in order to find novel associations of CDH17 in the different CRC subtypes. The gene discussed is CDH17; the disease is cancer.