TMPRSS2 and COVID-19: This is supported by several studies [4, 49–51] that found that the minor T allele of this variant is linked to a decrease in the severity of symptoms of COVID-19, and this is in line with the results of the meta-analysis that showed a significant association between the TMPRSS2 rs12329760 C-allele and an increased risk of developing severe COVID-19 [46].