A positive correlation between SRSF5 and PKM2 expression was also observed in CRC tissues (Fig. 8F), and the prognosis of CRC patients with high expression of both SRSF5 and PKM2 was significantly worse than that of CRC patients with other expression patterns (P = 0.0004, Fig. 8G). This evidence concerns the gene SRSF5 and colorectal carcinoma.