In the macrophage cell line (RAW264.7) under the stable condition, endogenous SCIMP protein could hardly be observed in the exosomes from the supernatant, while endogenous SCIMP protein was detected in the exosomes from the RAW264.7 cells after stimulation with denatured E. coli (ATCC#19183, Multiplicity of infection, MOI = 100) at 2 and 6 h but not observed with Lipopolysaccharides (LPS) (Fig. 1f). This evidence concerns the gene SCIMP and infection.