The combination of gene expression level differences across the eight cohorts showed that GRIA3, FADS2, FABP4, and PRKAA2 were upregulated in NASH, whereas NR4A1, IL6, ZFP36, and DHODH exhibited the opposite pattern (Fig. 6A-H). Here, FADS2 is linked to metabolic dysfunction-associated steatohepatitis.