NR1H4 and metabolic dysfunction-associated steatotic liver disease: FXR activation by hepatocellular Cystathionine γ lyase/H2S significantly alleviates the diet-induced NAFLD, while iron-induced FXR suppression leads to fatal hepatotoxicity in humans and mice.40 In this work, we found that Zbtb18 overexpression remarkably increased the FXR mRNA and protein levels and activated its target genes in livers and cultured MPHs by enhancing the nuclear-translocation of the FXR protein.