Zbtb11 cooperates with NRF-2 to control mitochondrial function.36Zbtb20 acts as a key regulator of hepatic lipogenesis, influencing systemic lipid homeostasis.37 Likewise, we found that Zbtb18 played effective roles in stimulating FAO and defending against the diet-induced NAFLD phenotype. The gene discussed is ZBTB18; the disease is metabolic dysfunction-associated steatotic liver disease.