Correspondingly, the MCD diet elicited expression of liver genes related to liver fibrosis development, including α-SMA, Col1a1, and TGF-β, was also stimulated in hepatic Zbtb18LKO mice, along with an impaired expression of FXR and of its target genes (Fig. 9e, f). Here, ACTA1 is linked to Hepatic fibrosis.