Correspondingly, the changes in liver weight/body weight ratio values, serum ketone body levels, and TGs contents in hepatic Zbtb18LKO mice were reversed due to the rescued activation of FXR, along with an improvement in the expression of hepatic genes involved in FAO and on the hepatic steatosis in these mice, as shown by the decreased ballooning due to lipid droplets accumulation in the hepatocytes (Fig. 8d–f). Here, NR1H4 is linked to fatty liver disease.