NR1H4 and metabolic dysfunction-associated steatotic liver disease: Moreover, gene set enrichment analysis (GSEA) of the above DEGs identified in Zbtb18 overexpressing MPHs and the liver from the NAFLD patients showed that “FXR signaling pathway” was positively correlated with Zbtb18 expression, suggesting that the expression of these DEGs may be driven by FXR-dependent mechanisms (Fig. 5e).