TREM2 and coronary artery disorder: For instance, Li and colleagues conducted RNA sequencing analysis of exosomes extracted from the plasma of patients with coronary artery disease (CAD) and discovered that miR-4498 from plasma exosomes can inhibit the expression of inflammatory cytokines such as Compatible Time-Sharing System (Ctss) and triggering receptor expressed on myeloid cells 2 (Trem2) [44].