Additionally, a study by Oliver and colleagues analyzed different bone marrow cell clusters in non-alcoholic fatty liver disease (NAFLD) liver using scRNA-seq, demonstrating the adaptation of bone marrow cells in the liver to NAFLD progression and the unique inflammatory phenotype characterized by down-regulation of inflammatory calcium-binding protein (S100A8/A9) in macrophages and dendritic cell subsets [64]. This evidence concerns the gene IGKV1D-22 and metabolic dysfunction-associated steatotic liver disease.