Findings pointing out Th17 relevance in MS pathogenesis have been reinforced by genetic investigations on single-nucleotide polymorphisms (SNPs) of IL12B (encoding for IL-12p40) and IL-23 receptor (IL23R) genes, identifying few specific SNPs (i.e. IL23R rs11209026) associated with increased MS susceptibility [150]. Here, IL12B is linked to myeloid sarcoma.