To date, we know that abnormal production of CKs in MS patients impairs glutamatergic and GABAergic synapses with a clear impact in cognitive decline [101, 102], as disbalance in several CKs, i.e. TNF-α, IL-1β, and GM-CSF have been found in both MS and EAE model [107, 108, 118, 119]. Here, TNF is linked to myeloid sarcoma.