Combinations of the key terms were used for data retrieval, including “atopic dermatitis,” “adipokine,” “leptin,” “adiponectin,” “resistin,” “visfatin,” “dipeptidyl peptidase-4,” “fatty acid binding protein,” “apelin,” and “zinc-α2-glycoprotein.” Studies that reported the expressions of the mentioned adipokines and adipokines-related genetic variations in patients with AD as well as animal and in vitro experiments focused on the molecular mechanism of adipokines in AD were involved. This evidence concerns the gene LEP and Alzheimer disease.