Additionally, the observed sex effects of Aβ-plaque dependent and independent microglia response were stable after controlling for the AD signature CSF markers (Aβ42/40 ratio, p-tau, tau/Aβ index) in a subset of the sample (intercept females with AD (n = 21): + 0.50 ± 0.14 vs. males with AD (n = 14): − 0.39 ± 0.18, p = 0.002; slope females with AD (n = 21): + 0.14 ± 0.04 vs. males with AD (n = 14): + 0.15 ± 0.05; p > 0.99). This evidence concerns the gene MAPT and Alzheimer disease.