Given that the lack of plectin expression in astrocytes induces bundling and redistribution of VFs and leads to a reduction in the size and abundance of plasmalemmal AQP4 aggregates, we propose that the migratory potential of GBM cells (in which we found the expression of plectin to correlate with that of AQP4) is plectin dependent. This evidence concerns the gene PLEC and glioblastoma.