Brigatinib triggers the apoptosis of colorectal cancer (CRC) cells via inducing ER stress mediated by oxysterol-binding protein-related protein 8 (ORP8)/ubiquitin-specific peptidase 5 (USP5), and protects ER stress through ER autophagy to optimize cancer treatment [6]. Here, OSBPL8 is linked to colorectal carcinoma.