USP5 and colorectal carcinoma: After treatment with Brigatinib on CRC cell lines HT29, RKO, SW620 and the human colonic mucosal epithelial cell line NCM460, brigatinib was found to trigger CRC by inducing ER stress mediated by oxysterol-binding protein-related protein 8 (ORP8) /ubiquitin-specific peptidase 5 (USP5) apoptosis, and brigatinib was also found to induce FAM134B-mediated ER-phagy.