This review primarily summarized signaling pathways and their regulators that are involved in selective autophagy in human cancers, such as the mitophagy receptors autophagy-related gene 32 (Atg32), BCL2/adenovirus E1B 19KDa-interacting protein 3 (BNIP3)/BNIP3-like (NIX), sequestosome 1 (p62/SQSTM1), Parkin/PINK1, NIX, FUN14 domain containing 1 (FUNDC1), and Smad ubiquitin regulatory factor 1 (SMURF1) signaling pathway. The gene discussed is SMURF1; the disease is cancer.