BRCA1 and ovarian carcinoma: Moreover, recent advancements have led to the creation of ovarian cancer organoids, which closely resemble the original tumors in histological and genomic features, offering potential for drug screening and understanding tumor dynamics.43, 44Kopper et al demonstrated the development of organoids from human ovarian surface epithelium, especially from women predisposed to ovarian cancer due to BRCA1/2 mutations.45These ovarian surface epithelium organoids, mirroring features like FT organoids with KRT8+ markers and distinct folds, face growth and long-term maintenance challenges.