This study includes 33 patients with TARDBP pathogenetic variants (TARDBP-ALS) (median age 61 years [interquartile range (IQR) 53–67], 8 female [24.2%]) and 928 patients with ALS not carrying the pathogenic variant (WT-ALS) (median age 67 years [IQR 59–74], 386 female [41.6%]). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.