One of the top miRNA genes, with a score of 6 points, is MIR16-1, which together with MIR15A (also with a high score in CMC) constitutes the above-mentioned MIR15A/16-1 cluster (also known as the DLEU2 – deleted in lymphocytic leukemia 2 locus), the first identified tumor suppressor miRNA locus deleted in >50% of cases of B-cell CLL (30,81,82). This evidence concerns the gene DLEU2 and lymphoid leukemia.