Moreover, SIRT5 plays a dual roleas a promoter/suppressor in lung cancer, hepatocellular carcinoma(HCC), breast cancer, and prostate cancer.17 SIRT6 controls cellular homeostasis, DNA repair, telomere maintenance,and metabolism.6 SIRT6 deacetylates H3K9and H3K56 to maintain genome stability and telomere function. This evidence concerns the gene SIRT6 and Familial prostate cancer.