HIF1A and cancer: In the cancer context, SIRT3 exhibitsa role that varies dependingon the specific circumstances, acting as a promoter of tumorigenesisin some types of cancer while acting as a tumor suppressor in others.84 Finley et al.85 havedemonstrated that SIRT3 is additionally involved in controlling glycolyticmetabolism by controlling the inducible factor-1α (HIF-1α)stability and activity.