SIRT3 and gallbladder cancer: SIRT3 also seems to be involved in ferroptosis,a cell death mechanismdifferent from the metabolism-independent ones, such as cell apoptosisand necrosis.98,99 Ferroptosis is driven by iron-dependentmembrane lipid metabolism dysfunction100 and can be considered as a tumor suppression mechanism.101 Liu et al.102 demonstratedthat SIRT3 can induce ferroptosis in gallbladder cancer (GBC).