Giventhe involvement of SIRT3 in these important pathways, its deregulationcan result in several human diseases, such as cancer73 as well as noncancer pathologies such as liver,110,111,189 heart,77,115,124 metabolic,43,108,137,139,186 age-related,125,126 kidney,123,133−137 neurodegenerative162 diseases, neuropathicpain,152 osteoarthritis,142 and also infective disease caused by HBV112 and COVID-19.113. Here, SIRT3 is linked to osteoarthritis.