Increased binding of HK II results in mitochondria-mediated apoptosisand can be linked to augmented cancer cell resistance to chemotherapeuticagents.234,2359 might have a role in metabolicreprogramming by activating SIRT3.91 Fuet al.171 screened a library of 22 stilbene-basedcompounds, including resveratrol monomers, oligomers, and some semisyntheticderivatives, to develop novel efficacious neuroprotective agents ableto activate SIRT3. The gene discussed is HK2; the disease is cancer.