Enhanced kidneyfunction is achieved by overexpressing SIRT3, which reduces oxidativedamage, mitigates inflammation, and inhibits the apoptosis of renaltubular epithelial cells.131 Acute kidneyinjury (AKI) is a condition with a decrease in glomerular filtrationrate characterized by an increase in serum creatinine concentrationor oliguria.132 In this way, SIRT3 canimprove mitochondrial biogenesis and energy generation to protectfrom AKI. Here, SIRT3 is linked to acute kidney injury.