It is noteworthy that SIRT3’s enzymatic functionwas crucial for the effective repression of HIF-1α target genesbecause mutated SIRT3 could not significantly reduce hypoxic GLUT1expression.85 SIRT3 may act as an oncosuppressorby regulating glycolytic and anabolic metabolism, as the loss of SIRT3in human cancer cells is associated with glycolytic gene expression.40 SIRT3 functions as the primary deacetylase forthe pyruvate dehydrogenase complex (PDC), deacetylating, and activatingPDC. The gene discussed is HIF1A; the disease is cancer.