Osteoarthritis (OA)is a disease that affects a large part of thepopulation.198 In this pathology, chondrocytesare degenerating due to several causes,199,200 such as mitochondrial dysfunction.201,202 Wang et al.142 demonstrated that SIRT3 very likely possessesprotective properties in OA by maintaining mitochondrial homeostasis.They found significantly decreased levels of SIRT3 in degenerativeknee articular cartilage and TNF-α treated chondrocytes. This evidence concerns the gene SIRT3 and osteoarthritis.