2 is a secondary metabolite derived from the seedsof blessed milk thistle (Silybum marianum), whichis especially known for its antioxidant and anti-inflammatory propertiesin the liver.1972 has beenshown to improve mitochondrial function by controlling SIRT3 levels,resulting in a protective activity against cisplatin-induced AKI.A study by Li et al.189 reports that SIRT3levels are lowered in tubular epithelial cells in a mouse model ofcisplatin-induced acute kidney injury and that administration of 2 increased its expression, improving mitochondrial bioenergeticsand kidney function. Here, SIRT3 is linked to acute kidney injury.