The SIRT3 protein exhibitsa broaddistribution in tissues abundantwith mitochondria, including but not limited to kidney, heart, brain,and liver tissues,27 thus regulating aging,neurodegeneration, and other diseases related to the aforementionedorgans (Table 1 and Figures 7,8).70 Moreover, SIRT3 is considereda double-edged sword in cancer development.71 This evidence concerns the gene SIRT3 and cancer.