In the last two decades, sirtuinsattained more and more attention because of their pivotal functionsin several biochemical contexts, such as the regulation of cytodifferentiation,transcription, cell cycle progression, inflammation, energetic metabolism,apoptosis, neuro- and cardio-protection, cancer initiation, and progression.6−8 Considering their shared conserved catalytic core domain, sirtuinsare divided into four subclasses: class I contains SIRT1, -2, and-3, mainly showing deacetylase activity. This evidence concerns the gene SIRT1 and cancer.