SIRT3 and heart disorder: Active GSK3β can resist the TGF-β/Smad3pathway that causes cardiac fibrosis.123 Furthermore, SIRT3 can deacetylate STAT3 to inhibit the fibrosiscaused by STAT3-NFATc2.124 Moreover, SIRT3has a role in the inhibition of autophagy and apoptosis in heart diseases.For instance, when SIRT3 deacetylases Ku70, it interacts with Baxand inhibits the apoptosis of cardiomyocytes.77