HMOX1 and chronic kidney disease: SIRT3 may inhibit the formationof kidney stones by regulating the erythroid 2-related factor (NRF2)/hemoxygenase1 (HO-1) pathway.137 Renal fibrosis canderive from chronic kidney diseases (CKD).138 SIRT3 can inhibit this pathological process both by activating FOXO3aand deacetylating and then activating GSK3β.123