SIRT3 and Alzheimer disease: It appears that SIRT3 is involved in safeguardingneural integrity, as evidenced by its notable neuroprotective attributes.A decline in SIRT3 expression has been associated with advanced stagesof AD, highlighting its potential significance in disease progression.163 Furthermore, a noteworthy observation has emerged:upregulating SIRT3 expression holds promise in mitigating certainpathological processes attributed to AD.164 Amid the multifaceted effects stemming from augmented SIRT3 expression,a notable outcome involves the deacetylation of SOD2.