SIRT3 and cardiac hypertrophy: In an in vivo study, they found that 8 attenuates cardiac hypertrophyinduced by an increase in pressure and fibrosis by upregulating SIRT3.The upregulation suppresses ROS production, which is one of the causesof cardiac fibrosis and vascular dysfunction processes underlyingcardiac hypertrophy.226 In their study,they found that 8 abolishes TGF-β/Smad signalingin hypertrophied hearts, thus blocking cardiac fibrosis.