SIRT3 may inhibit the formationof kidney stones by regulating the erythroid 2-related factor (NRF2)/hemoxygenase1 (HO-1) pathway.137 Renal fibrosis canderive from chronic kidney diseases (CKD).138 SIRT3 can inhibit this pathological process both by activating FOXO3aand deacetylating and then activating GSK3β.123. Here, GSK3B is linked to chronic kidney disease.