RHO and cardiac hypertrophy: SIRT3 can inhibit cardiac hypertrophy by inhibiting mTORsignaling via activating the LKB1–AMPK pathway.117 Moreover, SIRT3 can inhibit mTOR signalingand Rho/Rho-kinase signaling by deacetylating FOXO3a.118,119 ROS signaling can be inhibited by deacetylating SOD2.120 Another cardiac problem is hypertrophy-relatedlipid accumulation.