SIRT3 and nephrolithiasis: In AKI, SIRT3 can have a protective effect by decreasingthe acetylation of CypD and p53.133,134 The deacetylationof the latter blocks apoptosis in AKI.135 Moreover, SIRT3 can safeguard from AKI by deacetylating PGC-1αand mitochondrial complex I.136 Nephrolithiasis,a metabolic kidney disorder, primarily results from damage to renalepithelial cells caused by calcium oxalate.