Moreover, the expression levels of p-AKT, CD9, CD63 and PD-L1 in WT + lymphoma cell + IXA4 group showed little changes compared with WT + lymphoma cell group, further proving that activation of the IRE1/XBP1s signaling pathway by IXA4 does not activate the downstream AKT signaling pathway. The gene discussed is CD9; the disease is lymphoma.