In this study, activation of the Notch-1/IRE1/XBP1s signaling pathway in macrophages might further affect the development of DLBCL by regulating the secretion of IL-6 and IL-4, suggesting that the Notch-1/IRE1/XBP1s signaling pathway may influence the secretion of IL-6 and IL-4 by regulating the inflammatory/immune cell balance. Here, ERN1 is linked to diffuse large B-cell lymphoma.