Compared with WT + lymphoma cell group, the expressions of p-PERK and ATF6 slightly decreased and the expression of p-IRE1α was significantly inhibited in KO + lymphoma cell group, proving that p-IRE1α is a key downstream gene of Notch-1, and Notch-1 knockout can significantly block the expression of p-IRE1α. The gene discussed is ERN1; the disease is lymphoma.