LYN and uveitis: We chose this TCR because 1) TCR clonotype 2 was expanded in conventional P2-specific CD4 T cells in AireGW/+Lyn−/− mice with uveitis, but not found in the AireGW/+Lyn−/− mice without uveitis; 2) TCR clonotype 2 recognized the P2 epitope of IRBP with an intermediate affinity compared to the other tested TCR clonotypes; and 3) TCR clonotype 2 and other TCR clonotypes contained identical TCRβ chain or TCRα CDR3 sequences (SI Appendix, Fig. S1G).