None of 17 WT CD45.1+/CD45.2+ recipient mice developed spontaneous uveitis (Fisher’s exact test, WT vs. AireGW/+: P = 0.0323), indicating that immune tolerance to IRBP was efficiently achieved in the wild-type recipients, whereas it was incompletely achieved in AireGW/+ recipients. Here, RBP3 is linked to uveitis.