Moreover, the pathogenic potential of an immune response to IRBP has been shown by immunization of mice with IRBP or with some of its peptide epitopes in adjuvant, which induce experimental autoimmune uveitis (21), and by development of spontaneous uveitis in B10.RIII mice expressing a transgenic TCR specific to a major epitope of IRBP recognized by this strain (22). The gene discussed is RBP3; the disease is autoimmune uveitis.