Moreover, expression of Drosophila N-terminal truncated Lamin C or mutations representing human Lamin A laminopathy mutations in larval wall muscle result in lethality, mislocalization of nuclear membrane proteins, nucleo-cytoskeletal uncoupling, and locomotion defects (Coombs et al., 2021; Dialynas et al., 2010, 2012; Schulze et al., 2009; Shaw et al., 2022; Zwerger et al., 2013). The gene discussed is LMNA; the disease is laminopathy.