CD8A and neoplasm: To determine whether the IE1 or IE1mut treatment actives the T cells in peripheral the immune organs, the expression of CD8, CD69, CD107a, CD44, CD62L, IFN-γ, and TNF-α were evaluated in the cervical draining lymph nodes and spleen on the 28th day of implantation in tumor-bearing mice (Fig. 4F).