APOA2 and familial pancreatic carcinoma: The point estimation of the AUC of the apoA2-i Index to distinguish stage I and II of pancreatic cancer from healthy controls was 0.836 (95% CI 0.774–0.898), higher than that of CA19-9 (0.783, 95% CI 0.710–0.855) (Supplemental Fig. 5).