The results of our previous study on IPMN HGD, which is considered to be a non-invasive cancer, indicated that apoA2-ATQ/AT (sensitivity 70.6%, specificity 96.7%) had sufficiently higher sensitivity than CA19-9 (sensitivity 14.5%, specificity 98.9%) for detecting patients with IPMN HGD [27]. Here, APOA2 is linked to pancreatic intraductal papillary-mucinous neoplasm.