Inversion of chromosome 16, inv(16)(p13q22)/t(16;16)(p13;q22), found in 5%–7% of de novo acute myeloid leukaemia (AML), joins CBFB (16q22) and MYH11 (16p13) genes to form a chimeric oncoprotein that sequesters RUNX1. Here, MYH11 is linked to acute myeloid leukemia.