CSF2RB, also called granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 receptor common β-subunit, was highly activated in the liver of mice with NASH, aggravating liver tissue inflammation by promoting the production and differentiation of macrophages and granulocytes (Wessendarp et al., 2022). The gene discussed is CSF2; the disease is metabolic dysfunction-associated steatohepatitis.