Zhou et al. (2021) have reported that Western diets decrease FUT2 expression in the intestinal epithelium of mice and that the loss of Fut2 activity mitigates diet-induced bile acid accumulation, insulin sensitivity, and hepatic steatosis. The specific roles of CSF2RB, HSD17B14, and FUT2 in the enterohepatic dialog of NAFLD are unknown, warranting further studies to determine how the eight gut bacteria identified in our study regulate the involvement of these three genes in NAFLD progression. This evidence concerns the gene CSF2RB and metabolic dysfunction-associated steatotic liver disease.