Similarly, CML exosomes exposed to a TGF-β1 receptor inhibitor or a specific neutralizing TGF-β1 antibody significantly reverse the proliferation of CML cells compared to those exposed to TGF-β1 enriched LAMA84 exosomes (34). This evidence concerns the gene TGFB1 and chronic myelogenous leukemia, BCR-ABL1 positive.