In contrast, CIN signature 5 and 10 activities were significantly higher in IDH-MUT grade 4 astrocytomas relative to tumors of GBM-TS (Kruskal-Wallis test with Dunn’s post hoc test, respectively FDR = 0.016 and FDR = 0.0010, Figure 4B). This evidence concerns the gene IDH1 and astrocytoma (excluding glioblastoma).