This corresponded to an increase of secreted GDF15 concentration in NSCLC cell lines up to 2000x that observed in HBEC GFP;p53wt (PC-9, p< 0.0001; HCC4006, p< 0.001; H1975, p< 0.001; HCC4011, p< 0.001; H3255, p< 0.0001; Figure 5B). This evidence concerns the gene GDF15 and non-small cell lung carcinoma.