This finding underscores the significance of TDP-43 in ALS pathophysiology through a physically interacting protein encoded by RPA1. Previous studies have implicated the roles of RAB1 and RAB2 in disrupted vesicle trafficking in ALS, but not for this specific subpopulation (Parakh et al., 2018). The gene discussed is RPA1; the disease is amyotrophic lateral sclerosis.