In colorectal cancer (CRC), ZNRF3 and RNF43 mutations occur frequently (Giannakis et al. 2014; Bond et al. 2016; Tu et al. 2019; Vasaikar et al. 2019) and have been mainly associated with the potentiation of WNT signaling (Hao et al. 2012; Koo et al. 2012; Hao et al. 2016). This evidence concerns the gene ZNRF3 and colorectal carcinoma.