ZNRF3 and cancer: Using cBioPortal (Cerami et al. 2012; Gao et al. 2013), we also detected a negative correlation between ZNRF3/RNF43 expression and EGFR protein in multiple other cancer types, including prostate cancer where ZNRF3 or RNF43 is deleted or mutated with a rate of 5% (Fig. 1F).