Besides frequent deletions in ACC, ZNRF3 and RNF43 are also important tumor suppressors in the more commonly occurring colorectal cancer (CRC) (Koo et al. 2012; Bond et al. 2016); thus, we next analyzed the TCGA colorectal adenocarcinoma (n=629) and CPTAC colon adenocarcinoma (n=110) datasets. This evidence concerns the gene RNF43 and colon adenocarcinoma.