By incorporating RPPA-based (TCGA CO/READ) and mass spectrometry-based (CPTAC COAD) proteomic data, we also confirmed EGFR protein to be the one most negatively correlated with ZNRF3 and RNF43 mRNA expression in CRC (Fig. 1C and Fig. S1B–E). Here, RNF43 is linked to colorectal carcinoma.