ZNRF3 and colorectal carcinoma: By incorporating RPPA-based (TCGA CO/READ) and mass spectrometry-based (CPTAC COAD) proteomic data, we also confirmed EGFR protein to be the one most negatively correlated with ZNRF3 and RNF43 mRNA expression in CRC (Fig. 1C and Fig. S1B–E).