ZNRF3 and adrenal cortex carcinoma: Given the critical role of ZNRF3 in adrenal hemostasis (Basham et al. 2019) and its frequent deep deletion in approximately 20% of adrenocortical carcinomas (ACCs) (Assie et al. 2014), our initial focus was to examine the ACC dataset from TCGA, comprising 92 samples, to identify proteins exhibiting correlations with ZNRF3 mRNA levels.