RNF43 and cancer: Additionally, we found that the RNF43 G659Vfs*41 mutant, a hotspot frameshift mutation in human colorectal tumors that may not potentiate WNT signaling (Tu et al. 2019; Li et al. 2020), elevates EGFR protein levels, suggesting that this mutation may exert its oncogenic role in cancer through EGFR upregulation.