Conversely, overexpression of ZNRF3 and RNF43 suppresses cancer cell proliferation, migration and invasion, and drug resistance in multiple human cancer cell lines (Jiang et al. 2013; Zhou et al. 2013; Qiu et al. 2016; Pangestu et al. 2021; Radaszkiewicz et al. 2021). Here, ZNRF3 is linked to cancer.