After confirming that del17p is associated with reduced <i>POLR2A</i> levels in publicly available myeloma patient databases, we engineered <i>TP53</i> wild-type cells with a <i>TP53</i> knockout (KO), <i>POLR2A</i> knockdown (KD), or both, the latter to mimic del17p. This evidence concerns the gene POLR2A and plasma cell myeloma.