TP53 and plasma cell myeloma: After confirming that del17p is associated with reduced <i>POLR2A</i> levels in publicly available myeloma patient databases, we engineered <i>TP53</i> wild-type cells with a <i>TP53</i> knockout (KO), <i>POLR2A</i> knockdown (KD), or both, the latter to mimic del17p.