TF and neoplasm: SVs often manifest as DNA copy number alterations (CNA), but detecting CNA also suffers from very low TF in plasma.19,20 Tumor-specific translocations can be detected by discordant mate pairs in whole genome sequencing (WGS) data21 However, the detection of SVs by mate-pair analyses requires deep coverage and would be computationally very challenging in cfDNA with low TF.