NFKB1 and neoplasm: showed that hyperglycemia leads to an increase in intranuclear NF-κB in human subjects, that two of the target genes of NF-κB, such as cell cycle protein D1 and cMyc, play important roles in cell growth and proliferation, and that NF-κB itself regulates many genes involved in the process of cell proliferation, tumor formation, and metastasis, thereby influencing cancer development (61, 62).