In model 2, factors associated with the risk of developing prostate cancer included age (OR=1.056,95% CI [1.020,1.094], P=0.002), initial PSA (OR=1.059,95% CI [1.031,1.088], P<0.001), and TyG index (P for trend=0.001), the risk of prostate cancer in the highest quartile of the TyG index (Q4) was 3.387 times higher than that in the lowest quartile (Q1) (OR=3.387,95% CI [1.511,7.593], P=0.003). This evidence concerns the gene KLK3 and Familial prostate cancer.