NFKB1 and Familial prostate cancer: Metabolic syndrome is characterized by obesity, insulin resistance (IR), hypertension, and hyperlipidemia (17), and several current studies have demonstrated that insulin resistance is associated with prostate cancer, which can affect the development and progression of Pca through a variety of mechanisms, including the inflammatory pathway (Nuclear Factor Kappa B) (NF-κB) and cytokines, and increase the risk of developing prostate cancer (18–22).