Activation of the PI3K/Akt pathway promotes the phosphorylation of BAD that a pro-apoptotic Bcl2 family member in cells, phosphorylation of BAD inhibits the ability of BAD to bind and constrain the anti-apoptotic Bcl2 family members that BclxL and Bcl2, leading to apoptosis resistance in PCa cells, which in turn causes prostate cancer (54, 56). This evidence concerns the gene AKT1 and prostate cancer.