BCL2 and Familial prostate cancer: Activation of the PI3K/Akt pathway promotes the phosphorylation of BAD that a pro-apoptotic Bcl2 family member in cells, phosphorylation of BAD inhibits the ability of BAD to bind and constrain the anti-apoptotic Bcl2 family members that BclxL and Bcl2, leading to apoptosis resistance in PCa cells, which in turn causes prostate cancer (54, 56).